| Professional activity: |
Coordination of national research programs in the field of ovarian, breast, prostate, cervix, colon, pancreas; Implementation of microarray technology (Agilent- Whole Human Genome), PCR array and qRT-PCR in Functional Genomics Department; Functional genomics studies in malignant tumors; screening tests for cervical cancer (HPV); pharmacogenomic studies in breast cancer ; evaluation the effect of therapy for chronic myelogenous leukemia by BCR-ABL oncogenetic tests |
| Field of interest in research area: |
Molecular biology of cellular cycle, apoptosis and angiogenesis, tumor cells resistance to therapy, pharmacogenomics studies (microarray, PCR array, qRT-PCR). Pathology of interest: prostate, breast, cervix, ovary, pancreas, colon. |
| Research experience: |
National research experience:
Project director:
1. CNCSIS-IDEI - Identification through microarray technique of non-invasive predictive tumoral biomakers in prostate cancer.
2. CNMP (PNCD II) - The identification of the transcriptomic molecular profiles in advanced stage cervical cancer using functional genomic studies. CERVIX-array.
Project manager IOCN:
1. CNMP (PNCD II) Transcriptomic molecular profile definition in prediction of clinical status in breast cancers resistant to anthracyclines. Metastatic disease definition in relation to primary tumor. BREAST-OMICS.
2. CNMP (PNCD II) Identification the molecular response for detection and immune response in pancreas cancer. PANGEN
Member in 12 national projects – for IOCN partner (2004-2008), coordinating analysis of genomics, by qRT-PCR, and microarray- WHG.
Member in an international project: Malignant melanoma group–EORTC: (Marie Curie fellowship 2003-2004). Functional genomics study: MICROARRAY TECHNOLOGY DEVELOPMENT APPLIED TO CANCER DIAGNOSIS: Distant metastasis free survival of primary cutaneous melanoma is predicted by genome-wide expression profiling.
International Experience
• 2002: Perfectioning scholarship : World Bank Grant, Molecular Biology, Gustave Roussy Institute, Villejuif, France, Unity of Radiosensitivity UPRES EA 27-10
• 2004: Marie-Curie PhD fellowship (QLGA-1999-50406): Molecular Biology, Gustave Roussy Institute, Villejuif, France, Unity of functional genomics. Pharmacogenomics studies (microarrayand quantitative PCR) on nude mice and human xenografts; Transcriptomics and molecular genetics studies (molecular pattern) through microarray and real-time PCR (quantitative PCR) on malignant melanoma (EORTC melanoma group) and ovarian cancer.
• 2006: International Course of Bioinformatics using microarray data: Gene Spring for Systems Biology with Gene Spring GX and Ingenuity Pathway Analysis
• 2006: International summer school Varese, Italy– Insurbia International School on Breast Cancer and Melanoma : Biology, Diagnosis and Therapy
• 2006: International summer school Cluj-Napoca, Romania, Functional Genomics in Biology and therapy of cancer
• 2006: International Course microarray and bioinformatics, Heidelberg, Germany, Agilent Technologies Practical Course on Gene Expression Analysis using 60mer Oligonucleotide Microarrays and The 3rd EMBL Biennial Symposium: From Functional Genomics to Systems Biology.
• 2007: International Course miRNA profiling, Heidelberg, Germany: Practical Course - A joint EMBL/Agilent Technologies Practical Course on MicroRNA profiling..
• 2008: International Course, Breda Netherlands - Quantitative PCR Techniques, (36 eurocredits -UEC)
• 2008: International Course Aspen, USA - Molecular Biology in clinical Oncology
CNCSIS evaluative for national research projects –IDEI (2008-2011).
|