Dr. Fischer-Fodor Eva


Cercetator stiintific gradul II

Specialitatea Biochimie Medicala, Doctor in Chimie
Poziţia curentă: Cercetator stiintific gradul II
Chimist principal medical
in cadrul Departamentului de Cercetare, Institutul Oncologic “Prof.Dr.I.Chiricuta” Cluj-Napoca
Titluri ştiinţifice: Cercetator stiintific gradul II
Telefon de contact pentru pacienti: Tel/Fax. 0264439260
Studii
2008, Universitatea Babes-Bolyai, Cluj-Napoca, Doctorat in Chimie
1996, Universitatea Babes-Bolyai, Cluj-Napoca, Licenta in Chimie Organica
2014-2015, Universitatea de Medicina si Farmacie Iuliu Hatieganu, studii postdoctorale in medicina translationala
 
Activitate profesionala 1998-2002 - chimist in Laboratorul de Imunologie al IOCN
2003-2008 - chimist specialist biochimie medicals in cadrul Departamentului de Cercetare al IOCN
2008-2014- chimist principal medical in cadrul Departamentului de Cercetare al IOCN
2015- pina in prezent: cercetator stiintific gradul II la Laboratorul de Biologie Tumorala, Departamentul de Cercetare al IOCN
 
Competente Elaborarea publicatiilor stiintifice: autor principal sau co-autor al unui numar de 46 articole indexate de Web of Science, Clarivate Analytics; 25 de articole in jurnale nationale
- Factor Hirsch 12 (conform Web of Science, Clarivate Analytics)
- Sustinerea de prezentari stiintifice
- Elaborarea si implementarea proiectelor de cercetare: director sau responsabil de proiect in 3 proiecte nationale, 2 proiecte internationale, participanta in 26 de proiecte
- Studiul aplicatiilor metalomicii in medicina
- Studii fundamentale si translationale, in vitro si in vivo
- Izolarea si caracterizarea celulelor
- Implementarea unor metode metalomice bazate pe spectrometrie, fluorescenta si chemiluminiscenta
- Dezvoltarea si implementarea unor metode biochimice, biologice si imunologice pentru cercetarea oncologica si aplicatii clinice
- Metode imuno-enzimatice proteomice
- Studiul mecanismelor moleculare in radiobiologie si aplicatiile acestora in tratamentul cancerului
 
Domeniul de interes in cercetare Studiul compusilor nou sintetizati avind potential terapeutic
- Aplicatiile bio-medicale ale compusilor metalici cu rol de precursor de medicamente, ale compusilor organometalici, complecsilor metalelor si a biomaterialelor functionalizate cu metale
- Impactul metalelor asupra mediului si sanatatii
- Chimiorezistenta indusa de tratamentele oncologice si radiosensibilitatea celulelor normale si tumorale
- Identificarea de noi biomarkeri
- Modularea tintelor moleculare si a cailor de semnalizare prin actiunea compusilor naturali; aspecte de stres oxidativ
- Celule stem tumorale
- Imunologie celulara
- Elucidarea mecanismelor fina de reglare ale raspunsului imun prin intermediul receptorilor de co-stimulare
- Elucidarea mecanismelor de moarte celulara
- Citometrie statica si tehnici "cell on a chip"
 
Membru in asociatii profesionale American Chemical Society
Societatea Romana de Cancer
Ordinul Biochimistilor, Biologilor si Chimistilor in Sistemul Sanitar din Romania
Societatea Romana de Radioterapie si Radiologie Medicala
 
Studii Vizite de lucru si schimburi de experienta la Comenius University, Bratislava, Slovacia-2011 si 2014; University of Perugia, Italia-2005; University of Rennes 1, Frante-2006, Joliot Curie Institute in Budapesta, Ungaria-2008 si 2013, University Rene Descartes, Paris, Franta -2010,
- Curs de formare: From tissue to pure cells with MACS solutions, 2017, Bucuresti, Institutul de Biologie si Patologie Celulara Nicolae Simionescu
- EuroFlow Workshop in flow-cytometry, 2013, Sofia, Bulgaria
-Metal species toxicity testing by the use of in vitro models, Westfälische Wilhelms-Universität Münster, curs preconferinta a 2nd Metallomics Conference, Münster, Germany, 2011
- Laboratory diagnostics of malignant hemopathies through flow cytometry, UMF Carol Davila, Bucharest, Romania, 2004.
- Training Course on Radioactivity, Radionuclides and Radiation, Jozef Stefan Institute, Ljubljana, Slovenia, 2005.
- Functional genomics in cancer biology and therapy, Biogenero international summer school , UMF si IOCN Cluj Napoca, 2006.
- New technologies in clinical radiation oncology: implementation in Romania, Radmolbio international training course, UMF si IOCN Cluj Napoca, 2006. - Training course: Biomembranes and Molecular Medicine, UMF Cluj Napoca, 1999.
 
Publicatii recente
1. Modulation of the mechanism of apoptosis in cancer cell lines by treatment with silica-based nanostructured materials functionalized with different metallodrugs.
Díaz-García D, Cenariu D, Pérez Y, Cruz P, Del Hierro I, Prashar S, Fischer-Fodor E, Gómez-Ruiz S.
Dalton Trans. 2018 Sep 11;47(35):12284-122991.

2. Synthesis and antitumour evaluation of mono- and multinuclear [2+1] tricarbonylrhenium(I) complexes.
Giffard D, Fischer-Fodor E, Vlad C, Achimas-Cadariu P, Smith GS. Eur J Med Chem. 2018 Sep 5;157:773-781. doi: 10.1016/j.ejmech.2018.08.011

3. Exosomes at a glance - common nominators for cancer hallmarks and novel diagnosis tools. Gulei D, Petrut B, Tigu AB, Onaciu A, Fischer-Fodor E, Atanasov AG, Ionescu C, Berindan-Neagoe I. Crit Rev Biochem Mol Biol. 2018 Oct;53(5):564-577

4. Low-dose radiations derived from cone-beam CT induce transient DNA damage and persistent inflammatory reactions in stem cells from deciduous teeth. Virag P, Hedesiu M, Soritau O, Perde-Schrepler M, Brie I, Pall E, Fischer-Fodor E, Bogdan L, Lucaciu O, Belmans N, Moreels M, Salmon B, Jacobs R. Dentomaxillofac Radiol. 2018 Aug 31:20170462.

5. Phytochemical Analysis of Anti-Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts.Andreicut AD, Pârvu AE, Mot AC, Pârvu M, Fischer Fodor E, Cătoi AF, Feldrihan V, Cecan M, Irimie A. Oxid Med Cell Longev. 2018 Jun 27;2018:2879793.

6. Multifunctional applications of a dysprosium-based metal–organic chain with single-ion magnet behaviour.
Fernández B, Oyarzabal I, Fischer-Fodor E, Macavei S, Sánchez I, Seco J.M., Gómez-Ruiz S, Rodríguez-Diéguez A. CrystEngComm, 2016,18, 8718-8721.

7. Synthesis of structural analogues of hexadecylphosphocholine and their antineoplastic, antimicrobial and amoebicidal activity. Timko L, Fischer-Fodor E, Garajová M, Mrva M, Chereches G, Ondriska F, Bukovský M, Lukáč M, Karlovská J, Kubincová J, Devínsky F. Eur J Med Chem. 2015;93:263-73.

8. Iron, inflammation and invasion of cancer cells. Fischer-Fodor E, Miklasova N, Berindan-Neagoe I, Saha B. Clujul Med. 2015;88(3):272-7.

9. Green synthesis, characterization and anti-inflammatory activity of silver nanoparticles using European black elderberry fruits extract.
David L, Moldovan B, Vulcu A, Olenic L, Perde-Schrepler M, Fischer-Fodor E, Florea A, Crisan M, Chiorean I, Clichici S, Filip GA. Colloids Surf B Biointerfaces. 2014;122:767-77.

10. Synthesis and characterization of new biologically active palladium(II) complexes with (1E,6E)-1,7-bis(3,4-diethoxyphenyl)-1,6-heptadiene-3,5-dione
Miklášová N, Fischer-Fodor E, Mikláš R, Kucková L, Kožíšek J, Liptaj T, Soritau O, Valentová J, Devínsky F
Inorg. Chem.Commun. 2014, 46: 229–233.

11. Oxidative protection of hemoglobin and hemerythrin by cross-linking with a nonheme iron peroxidase: potentially improved oxygen carriers for use in blood substitutes. Hathazi D, Mot AC, Vaida A, Scurtu F, Lupan I, Fischer-Fodor E, Damian G, Kurtz DM Jr, Silaghi-Dumitrescu R. Biomacromolecules. 2014;15(5):1920-7.

12. Anti-cancer applications of titanocene-functionalised nanostructured systems: an insight into cell death mechanisms. Ceballos-Torres J, Virag P, Cenariu M, Prashar S, Fajardo M, Fischer-Fodor E, Gómez-Ruiz S.
Chemistry. 2014; 20(34):10811-28.

13. Gallium phosphinoarylbisthiolato complexes counteract drug resistance of cancer cells.
Fischer-Fodor E, Vălean AM, Virag P, Ilea P, Tatomir C, Imre-Lucaci F, Schrepler MP, Krausz LT, Tudoran LB, Precup CG, Lupan I, Hey-Hawkins E, Silaghi-Dumitrescu L. Metallomics. 2014; 6(4):833-44.

14. Oxaliplatin induces different cellular and molecular chemoresistance patterns in colorectal cancer cell lines of identical origins. Virag P, Fischer-Fodor E, Perde-Schrepler M, Brie I, Tatomir C, Balacescu L, Berindan-Neagoe I, Victor B, Balacescu O. BMC Genomics. 2013;14:480.

15. Anticancer and antimicrobial activities of some antioxidant-rich cameroonian medicinal plants.
Tamokou Jde D, Chouna JR, Fischer-Fodor E, Chereches G, Barbos O, Damian G, Benedec D, Duma M, Efouet AP, Wabo HK, Kuiate JR, Mot A, Silaghi-Dumitrescu R.
PLoS One. 2013; 8(2):e55880

16. Antiproliferative effect of novel platinum(II) and palladium(II) complexes on hepatic tumor stem cells in vitro. Miklášová N, Fischer-Fodor E, Lönnecke P, Tomuleasa CI, Virag P, Schrepler MP, Mikláš R, Dumitrescu LS, Hey-Hawkins E. Eur J Med Chem. 2012;49:41-7.
 
Premii
 Premierea rezultatelor stiintei UEFISCDI – articole:
23 premii intre anii 2008-2018

Diploma de excelenta si medalie de aur –International Inventica Compartment, PRO INVENT, IXth ed, 2011, Cluj-Napoca.

Diploma de excelente –aniversarea a 10 ani de existenta a Ordinului Biochimistilor, Biologilor si Chimistilor in Sistemul Sanitar din Romania (OBBCSSR), 2014, Bucharest.

Diploma si medialie de aur - Euroinvent 2015, European Exhibition of Creativity and Innovation, Universitatea de Medicina si farmacie „Iuliu Hatieganu”

Diploma de excelenta a Universitatii Tehnice din Moldova, 2015, Republica Moldova, Ministerul Educatiei

The Hamangia Thinker gold medal with special mention of the jury , The XIXth International Exhibition of Research, Innovation and Technological Transfer „INVENTICA 2015”, Iasi, Romania