Biology and Therapy of Cancer Cell
The Official Journal of „Ion Chiricuta” Cancer Institute
Comprehensive Cancer Center
Editor-in-Chief
Alexandru Irimie, Cluj-Napoca, Romania
Associate editors
Ioana Neagoe, Cluj-Napoca, Romania
Patriciu Achimas Cadariu, Cluj-Napoca, Romania
Valentin Cernea, Cluj-Napoca, Romania
Editorial Board
Baciut Grigore – Cluj-Napoca, Romania
Badea Radu – Cluj-Napoca, Romania
Balacescu Ovidiu – Cluj-Napoca, Romania
Beuran Mircea – Bucure?ti , Romania
Bojan Anca – Cluj-Napoca, Romania
Bojita Marius – Cluj-Napoca, Romania
Buiga Rares – Cluj-Napoca, Romania
Burz Claudia – Cluj-Napoca, Romania
Cainap Calin – Cluj-Napoca, Romania
Chiricuta Cristian – Limburg, Germany
Ciuce Constantin – Cluj-Napoca, Romania
Ciuleanu Tudor – Cluj-Napoca, Romania
Cotarla Ion – Washington, USA
Cozma Vasile – Cluj-Napoca
Cristea Victor – Cluj-Napoca, Romania
Cucuianu Andrei – Cluj-Napoca, Romania
Fetica Bogdan – Cluj-Napoca, Romania
Florian Stefan– Cluj-Napoca, Romania
Fosse Philippe – Paris, France
Gavrilescu Doru – New York, USA
Gillies Alan – Preston, United Kingdom
Green John – Liverpool, United Kingdom
Groza Ioan – Cluj-Napoca,Romania
Köhler Christhardt – Berlin, Germany
Falus Andras – Budapest, Ungaria
Lazar Vladimir – Villejuif, France
Leucuta Sorin – Cluj-Napoca, Romania
Llombart-Bosch Antonio – Valencia, Spain
Lumniczky Katalin – Budapest, Hungary
Muntean Valentin – Cluj-Napoca, Romania
Muresanu Dafin Fior – Cluj-Napoca, Romania
Nagy Viorica – Cluj-Napoca, Romania
Nicula Florian – Cluj-Napoca, Romania
Petrut Bogdan – Cluj-Napoca, Romania
Piciu Doina – Cluj-Napoca, Romania
Popita Vasile – Cluj-Napoca, Romania
Rancea Alin – Cluj-Napoca, Romania
Reed Nick – Glasgow, England
Sabourin Jean Christophe – Rouen, France
Safiye Aktas – Izmir, Turkey
Safrany Geza – Budapest, Hungary
Simionescu Maya – Bucharest, Romania
Sitaru Cassian – Freiburg,Germany
Smith Edvard – Stockholm, Sweden
Vilda Pedro Gomez – Madrid,Spain
Virag Piroska – Cluj-Napoca, Romania
Vlad Anda – Pittsburgh, USA
About „Biology and Therapy of Cancer Cell”Journal (the BTCC Journal)
The Official Journal of „Ion Chiricuta” Cancer Institute – Comprehensive Cancer Center
Aims and scope
The „Biology and Therapy of Cancer Cell”Journal (the BTCC Journal) is the Official Journal of „Ion Chiricuta” Cancer Institute – Comprehensive Cancer Center.
The „Biology and Therapy of Cancer Cell” Journal is an international peer-review, interdisciplinary journal published four times a year.
Each number shall have an invited Guest Editor to devote an issue on a specific scientific area.
The Editors of our journal welcome contributions from our readers.We seek high quality clinical and basic research reports from all aspects.
Topics shall cover gene discovery and therapy of cancer at clinical and preclinical stage (surgical oncology, medical oncology,radiation oncology, nursing oncology, supportive care and psychooncology), haematology, molecular mechanisms and personalised medicine, therapeutic options and novelties in cancer, cancer immunotherapy, DNA vaccines, RNA interference, post transcriptional control of gene expression, cell therapy, stem cells therapies, major discoveries in cancer therapy,cancer epidemiology,social and ethical and bioethical aspects of cancer. The journal will provide integrated view of modern oncology across all disciplines. Each discipline is represented in the Editorial Board.
Editor-in-Chief
Alexandru Irimie
Cluj-Napoca, Romania
Associate Editors
Ioana Neagoe, Cluj-Napoca, Romania
Patriciu Achimas Cadariu, Cluj-Napoca, Romania
Valentin Cernea, Cluj- Napoca,Romania
Scientific Publications Office
“Ion Chiricuta” Cancer Institute – Comprehensive Cancer Center
34-36 Republicii st.
400015 Cluj- Napoca
Romania
T: +40 264 450749 int.173
F: +40 264 598885
e mail adress: ioanaberi@iocn.ro
Subscription:
Individual rate for 2009 – 12 euros (2 issues printed or on line)
for 2010 – 24 euros (4 issues printed or on line)
Institutional rate for 2009 – 15 euros
for 2010 – 30 euros
Single issue 7 euros inclusive the postal costs for individual.
For subscription orders, requests for samples copies or any other informations considering the review please send your request to:
Ioana Neagoe – Associate Editor
T: +40 264 450749 int.173
F: +40 264 598885
e mail adress: ioanaberi@iocn.ro
For the first number of the journal published in october 2009, all the correspondence with the authors of the articles shall be done through
Associate Editor – Ioana Neagoe via e mail: ioanaberi@iocn.ro
© “Ion Chiricuta” Cancer Institute – Comprehensive Cancer Center
ISSN 2066 - 7558
EIKON Publishing House, 2009
CNCSIS accreditation code 132
ISBN 978-973-757-254-7
Cluj-Napoca, Bucuresti Street nr. 3A
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Phone
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0364-117246, 0728-084801
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web
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www.edituraeikon.ro
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e-mail
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edituraeikon@gmail.com,
edituraeikon@yahoo.com
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Cover design: Sorin Luca
Designer: Cristina Brai?
Manuscript submission
Online submission is now available at:
http://www.iocn.ro/Detaliu.aspx?t=prezentareRevista
Authors are strongly encouraged to submit on-line to facilitate the review process.
Please refer to the information for Authors before submitting a manuscript.
Papers must be submitted on the understanding that they have not been published elsewhere (except in the form of an abstract or as part of a published lecture, review, or thesis) and are not currently under consideration by another journal published by any other publisher.
For any enquires concerning the publicaton:
Ioana Neagoe, Associate Editor
“Ion Chiricuta” Cancer Institute – Comprehensive Cancer Center
34-36 Republicii st.
400015 Cluj- Napoca
Romania
T: +40 264 450749 int.173 / +40 743 111 800
F: +40 264 598885
e-mail: ioanaberi@iocn.ro
Authors are advised to supply the names of three potential referees and/or referees they do not wish to review their paper.
Manuscripts will be handled by the Editor and authors are asked to supply the name of the appropriate person.
© No part of the material may be reproduced or utilized in form or by any means,electronic or mechanical, including photocopying , recording or by any information storage and retrieval system, without written permission from the copyright owner „Ion Chiricuta” Cancer Institute – Comprehensive Cancer Center.
Instruction for authors
PREPARATION OF MANUSCRIPTS
Reviews – up to 30 printed pages
Review series – up to 20 printed pages – 100 references
Short review – up to 10 printed pages -50 references
Research Papers or Regular Manuscripts (up to 20 printed pages)
Brief Communications, Brief Reports
Editorials, Commented images, Points of View
Letters to the Editor (not to exceed 5 pages)
Medical Hypotheses (not to exceed 3 pages)
Valuable ideas and discoveries
Views and Commentaries
Progress and Trends in cancer research and therapy
News, Meeting Reports, Book Reviews (not to exceed 3 pages)
Author Guidelines
Submission
Manuscripts should be submitted by one of the authors of the manuscript through the online Manuscript Submission on line system . Regardless of the source of the word-processing tool, only electronic PDF (.pdf) or Word (.doc, .docx, .rtf) files can be submitted through the MSS. Pages are limited as seen previously.Online submissions are preferred to facilitate rapid publication and minimize administrative costs. Submissions by anyone other than one of the authors will not be accepted. The submitting author takes responsibility for the paper during submission and peer review. If for some technical reason submission through the MSS is not possible, the author can contact Scientific Office or ioanaberi@iocn.ro for support.
Format; all text shall be in Times New Roman /Arial 12 space 1.5.
Terms of Submission
Papers must be submitted on the understanding that they have not been published elsewhere (except in the form of an abstract or as part of a published lecture, review, or thesis) and are not currently under consideration by another journal published by any other publisher. The submitting author is responsible for ensuring that the article’s publication has been approved by all the other coauthors. It is also the authors’ responsibility to ensure that the articles emanating from a particular institution are submitted with the approval of the necessary institution. Only an acknowledgment from the editorial office officially establishes the date of receipt. Further correspondence and proofs will be sent to the author(s) before publication unless otherwise indicated. It is a condition of submission of a paper that the authors permit editing of the paper for readability. All enquiries concerning the publication of accepted papers should be addressed to ioanaberi@iocn.ro
Peer Review
All manuscripts are subject to peer review and are expected to meet standards of academic excellence. Submissions will be considered by an associate editor and if not rejected right away, shall be sent to peer-reviewers (whose identities will remain anonymous to the authors).
Units of Measurement
Units of measurement should be presented simply and concisely using System International (SI) units.
Title and Authorship Information
The following information should be included
Paper title
Full author names
Full institutional mailing addresses
Email addresses
Corresponding author
Abstract
The manuscript should contain an abstract. The abstract should be self-contained and citation-free and should not exceed 250 words.
Introduction
This section should be succinct, with no subheadings, except review and short reviews.
Materials and Methods
This part should contain sufficient detail so that all procedures can be repeated. It can be divided into subsections if several methods are described.
Results and Discussion
This section may each be divided by subheadings or may be combined.
Conclusions
This should clearly explain the main conclusions of the work highlighting its importance and relevance.
Acknowledgments
All acknowledgments (if any) should be included at the very end of the paper before the references and may include supporting grants, presentations, and so forth.
References
Authors are responsible for ensuring that the information in each reference is complete and accurate. All references must be numbered consecutively and citations of references in text should be identified using numbers in square brackets (e.g., “as discussed by Smith [9]”; “as discussed elsewhere [9, 10]”). All references should be cited within the text; otherwise, these references will be automatically removed.The preffered form for the reference is authors name (first seven authors et al. if there are), title of the publication- italic and bold, journal of appearance, year, volume, number, pages
Preparation of Figures
Each figure should be supplied in a separate electronic or printed file. All figures should be cited in the paper in a consecutive order. Figures should be supplied in either vector art formats (Illustrator, EPS, WMF, FreeHand, CorelDraw, PowerPoint, Excel, etc.) or bitmap formats (Photoshop, TIFF, GIF, JPEG, etc.). Bitmap images should be of 300 dpi resolution at least unless the resolution is intentionally set to a lower level for scientific reasons. If a bitmap image has labels, the image and labels should be embedded in separate layers.
Preparation of Tables
Tables should be cited consecutively in the text. Every table must have a descriptive title and if numerical measurements are given, the units should be included in the column heading. Vertical rules should not be used.Each table should be supplied in a separate electronic or printed file.All tables legends should be supplied electronic or printed in a separate file.
Proofs
Corrected proofs must be returned to the publisher within 2-3 days of receipt. The publisher will do everything possible to ensure prompt publication. It will therefore be appreciated if the manuscripts and figures conform from the outset to the style of the journal.
The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
While the advice and information in this journal are believed to be true and accurate on the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.
Disclosure Policy
A competing interest exists when professional judgment concerning the validity of research is influenced by a secondary interest, such as financial gain. We require that our authors reveal all possible conflicts of interest in their submitted manuscripts.
Ethical Guidelines
New methods and ethically relevant aspects must be described in detail, bearing in mind the following:
I) Human Experiments/Research
All work must be conducted in accordance with the Declaration of Helsinki (1964). Papers describing experimental work/research on human subjects who carry a risk of harm must include:
A statement that the experiment/research was conducted with the understanding and the consent of the human subject.
A statement that the responsible Ethical Committee has approved the experiments/research.
Any form of registration that may identify a patient must be excluded from the content of the paper. When clinical photographs of patients are submitted, consent by the patient must be obtained prior to submission of the article and is the responsibility of the author.
II) Animal Experiments
Papers describing experiments on living animals should provide:
A full description of any anaesthetic and surgical procedure used.
Evidence that all possible steps were taken to avoid animal suffering at each stage of the experiment. Papers describing experiments on isolated tissues must indicate precisely how the donor issues were obtained.
Welcome to the new Journal / 11
Word of the Editor-in-Chief, Alexandru Irimie
review
R. Buiga, R. Pais, A. Irimie, L. Lelutiu, L. Rogojan, O. Balacescu, C.D. Olinici
Human papilloma virus and the molecular biology of cervical carcinogenesis. A review / 12
I. Cotarla
Signal transducer and activator of transcription 5a (Stat5a) - a critical player in mammary gland development and breast cancer / 27
C. Catana, I. Berindan-Neagoe, V. Cristea
Cytokine Profile in Immunosenescence / 36
original research reports
A.C. Rancea, V. M. Nagy, N. Todor, A. Irimie, V. Cernea, P. Achimas Cadariu, O. Coza, G. Kacso, A. Tr?il?, D. Eniu, C. Ordeanu, D. Todea
Predictive factors for residual tumor in a phase III prospective randomized trial: radio-chemotherapy plus surgery vs radio-chemotherapy in stage IIB cervical cancer. Interim results / 45
A. Cucuianu, K. Dohner, D. Dima, R. Schlenk, M. Schmidt, M. Patiu, C. Basarab, C. Selicean, A. Bojan, A. Vasilache, L. Urian,
T. Torok, M. Zdrenghea, H. Dohner, L. Petrov
The Role of Cytogenetics and Molecular Genetics in the Management of Acute Myeoid Leukemia / 51
I. Moldovan, G. Baciut, M. B?ciut, C. Dinu, H. Rotaru, S. Bran, I. Mitre, L. Hurubeanu, B. Opris
Functional neck dissection in oral and maxillofacial cancer / 57
R. Ola, I. Berindan-Neagoe, O. Balacescu, I. Diaconu, A. Mougsen, A. Dricu
The methylation profile of p16 and rb1 tumor suppressor genes in NSCLC and glioblastoma cell lines / 64
P. Virag, E. Fischer-Fodor, I. Brie, M. Perde-Schrepler, F. Vasile, O. Barbos, I. D. Postescu, V. I. Cernea
Immediate cytogenetic effects of computed tomography on leukocytes / 73
short communication
C. Braicu, I. Berindan-Neagoe, C. Burz, O. Balacescu, A. Irimie
Catechins-therapeutic implications in cancer / 81
commented images
M. Patiu
“Flaming” plasma cells / 85
case reports
St. I. Florian, E. Mihut, D. Cernea, C. Abrudan, C. Suciu, Z. Andrasoni
Giant Infra and Supratentorial Medulloblastoma in an under 3 years old child. Case study / 86
A. Bojan, L. Urian, A. Cucuianu, T. Torok, M. Zdrenghea, A. Vasilache, M. Patiu, C. Basarab, C. Coldea, D. Piciu, R. Buiga,
B. Fetica, L. Petrov
Primary Bone Lymphoma of the Tibia / 92
introducing a research project
A. Irimie, O. Balacescu, I. Berindan-Neagoe
BREAST – OMICS. Pharmacogenomics in breast cancer – a challenge for elucidating the chemoresistance to anthracyclines treatment / 96